The possibility of reactivation of herpes simplex virus as a result of photodynamic therapy — case report


photodynamic therapy
herpes simplex virus
actinic keratosis

How to Cite

Szymoniak‑Lipska M, Dańczak‑Pazdrowska A, Pazdrowski P, Żaba R, Adamski Z, Polańska A. The possibility of reactivation of herpes simplex virus as a result of photodynamic therapy — case report. JoFA [Internet]. 2019 Oct. 10 [cited 2023 Mar. 31];2(2):118-22. Available from:


Actinic keratosis (AK) is a common disorder, presented with scaly, erythematous lesions associated with chronic exposure to ultraviolet (UV) radiation and possible transforming into an invasive squamous cell carcinoma. Photodynamic Therapy (PDT) is one of non-invasive methods of treatment AK. We report the case of a 61-year-old female patient with AK treated with PDT in whom erythema and pustules with concomitant elevated body temperature were observed, what might indicate on reactivation of herpes simplex virus (HSV) infection.


Morton C, Szeimies RM, Sidoroff A, Wennberg AM, Basset‑Seguin N, Calzavara‑Pinton P, Gilaberte Y, Hofbauer G, Hunger R, Karrer S, Lehmann P, Piaserico S, Ulrich C, Braathen L. EuropeanDermatology Forum Guidelines on topical photodynamic therapy. Eur J Dermatol. 2015;4:296–311.

Charakterystyka Produktu Leczniczego Alacare. (dostęp 23.07.2019 r.).

Osiecka BJ, Nockowski P, Kwiatkowski S, Szepietowski JC. Photodynamic Therapy with Red Light and 5-Aminolaevulinic Acid for Herpes Simplex Recurrence: Preliminary Results. Acta Derm Venereol. 2017;10:1239–1240.

Monjo AL, Pringle ES, Thornbury M, Duguay BA, Monro SMA, Hetu M, Knight D, Cameron CG, McFarland SA, McCormick C. Photodynamic Inactivation of Herpes Simplex Viruses. Viruses. 2018;10:532.

Marotti J, Aranha AC, Eduardo Cde P, Ribeiro MS. Photodynamic therapy can beeffective as a treatment for herpessimplexlabialis. Photomed Laser Surg. 2009;2:357–63.

Zverev VV, Makarov OV, Khashukoeva AZ, Svitich OA, Dobrokhotova YE, Markova EA, Labginov PA, Khlinova SA, Shulenina EA, Gankovskaya LV. In vitro studies of the antiherpeticeffect of photodynamic therapy. Lasers Med Sci. 2016;5:849–55.

Nobbe S, Trüeb RM, French LE, Hofbauer GF. Herpes simplex virus reactivation as a complication of photodynamic therapy. Photodermatol Photoimmunol Photomed. 2011;1:51–2.

Yoon KC, Im SK, Park HY. Recurrentherpessimplexkeratitisafterverteporfinphotodynamictherapy for cornealneovascularization. Cornea. 2010;4:465–7.

Gilbert S, McBurney E. Use of valacyclovir for herpessimplex virus-1 (HSV-1) prophylaxis after facial resurfacing: A randomized clinical trial of dosing regimens. Dermatol Surg. 2000;1:50–4.